Aug 2026· Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie· 0 citations· 40 references
Medicine
TL;DR
PSTX incubation blocked TRPM2-mediated Ca2+ signaling, reducing AMD-induced mitochondrial oxidant injury and cell death and PSTX, a new TRPM2 antagonist, may be utilized to treat oxidative stress and aberrant Ca2+ influx induced by AMD.
Excessive generations of apoptosis and oxygen free radicals (OFRs) are two main common reasons of age-related macular degeneration (AMD). A homeopathic preparation of the Tarantula Cubensis spider venom is Theranekron (TNE). The antiapoptotic and antioxidant actions of TNE were indicated in different disease models exc...
M. Argun, Ö. Çelik· Journal of Cellular Neurosci...· 0 citations
Findings suggest that EGCG alleviates RPE damage associated with NF-κB p65-mediated ferroptosis, providing new insights into AMD pathogenesis and a promising therapeutic strategy.
Xiao-Yang Chen, Miao Han, Yi-Wen An et al.· Experimental Eye Research· 0 citations
Introduction Icariside II (ICS II), a major bioactive flavonoid metabolite from Epimedium, has been reported to exert neuroprotective effects, but its role in regulating mitochondrial dysfunction-related neuronal injury in Alzheimer’s disease (AD) has not been fully clarified. Methods In this study, we administered ICS...
Si-Yu Shan, Jia-Ming Bai, Yu Tian et al.· Frontiers in Pharmacology· 0 citations
HBO exposure through TRPA1-mediated Ca2+ signaling, induces mitochondrial oxidative cell cytotoxicity and death, which may offer a treatment option for HPO-induced retinal disorders linked to increased OFR and Ca2+ influx.
M. Argun, Mustafa Nazıroğlu· International Journal of Oph...· 0 citations
Eugenol exerts neuroprotective effects in glaucoma excitotoxicity models by suppressing ferroptosis through Mfn2-mediated regulation of mitochondrial-LD homeostasis and the SLC7A11/GSH/GPX4 antioxidant pathway.
Qian Wang, Le-Meng Feng, Cheng Zhang et al.· Molecular and Cellular Bioch...· 0 citations
