BACKGROUND
The accurate detection of clinical symptoms in electronic health records (EHRs) is pivotal for advancing large-scale genetic and longitudinal studies in psychiatry. Free-text clinical notes are an essential source of symptom-level information, particularly in psychiatry; however, the automated extraction of...
C. Frydman-Gani, A. Arias, M. Perez Vallejo et al.· Journal of Medical Internet...· 0 citations
In this study, we present the largest rare coding variant association study of schizophrenia to date, with 87,959 schizophrenia cases and 150,587 controls. We identify 16 genes at exome-wide significance: SETD1A, ZMYM2, HERC1, RB1CC1, SCAF1, XPO7, SP4, FYN, PPP3CA, CUL1, HDAC9, JARID2, ATP9A, PTK2, STAG1, and SCN2A, an...
J. Sealock, C. Dowd, Calwing Liao et al.· bioRxiv· 1 citation
The brain-gut-microbiome system is an integrated communication network linking the central nervous system, enteric nervous system, immune pathways, and intestinal microbiota. Increasing evidence indicates that dysregulation of this bidirectional signaling system contributes to both gastrointestinal and psychiatric diso...
Lin Chang, N. Freimer, E. Hsiao· Annual Review of Physiology· 0 citations
Together, these results implicate a constellation of rare variants that map onto neuronal biology and demonstrate that diverse global populations converge on shared genetic signals underlying BD risk.
Calwing Liao, Robert Ye, J. Sealock et al.· medRxiv· 0 citations
Genetic studies of serious mental illness (SMI, including schizophrenia and bipolar disorder) have implicated two classes of risk variant: common variants1-3, each of small effect but collectively accounting for most population-level risk, and ultra-rare coding variants4,5 which confer large risk in a small number of i...
Greta Gerdes, V. Tozzo, S. Service et al.· medRxiv· 0 citations
Bipolar disorder’s genetic architecture appears hierarchical—a general liability resolving into dimensions of course and comorbidity, beyond subtypes, beyond subtypes.
Tracey van der Veen, M. Tesfaye, J. M. K. Yang et al.· Research Square· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
