Author

N. Narisu

3 papers indexed here

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Open access Oct 2026

Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation.

Skeletal muscle tissue underlies several polygenic metabolic traits and diseases. Identifying their genetic mechanisms requires pinpointing cell types, regulatory elements, target genes and causal variants. Here we use genetic multiplexing to generate population-scale single-nucleus chromatin accessibility (single-nucl...

Arushi Varshney, Nandini Manickam, Peter Orchard et al. · Nature Genetics · 0 citations

Open access Aug 2026

Integrated Analysis of Skeletal Muscle Transcriptional Networks Characterizes Dysregulation in Pathways and Trait-Associated Regulatory Regions in Type 2 Diabetes

Together, the results reveal dysregulation in pathways in muscle tissue from individuals with diabetes, identify candidate drivers, and connect the genomic drivers of this dysregulation across type 2 diabetes and related metabolic traits.

A. Maddox, Nandini Manickam, Peter Orchard et al. · bioRxiv · 0 citations

#gene editing Open access Sep 2026

In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson‐Gilford Progeria Syndrome

In vivo delivery of a locus‐specific DNA base editor to bone tissue is demonstrated, the timing of treatment required for maximum efficacy is delineated, and it is suggested that this system might be tailored for application to other monogenic bone disorders.

Wayne A. Cabral, Caleb M. Grenko, Diana Yeritsyan et al. · Aging Cell · 0 citations