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Open access Sep 2026

Multiplatform single-cell and spatial transcriptomics reveal sex-specific malignant states and architecture in male breast cancer

Male breast cancer (MBC) is rare and remains largely managed using knowledge derived from female breast cancer. Here, we generated a multiplatform single-cell and spatial transcriptomic atlas integrating scRNA-seq, SeekSpace, Visium HD, Xenium In Situ, and multiplex immunohistochemistry data from male and female breast...

Hao-Yuan Shi, Xiu-Li Zhang, Shou-Liang Cai et al. · 0 citations
Open access Aug 2026

Discovery of modifiable factors associated with Pan-Cancer Risk: An Exposome-Wide analysis.

INTRODUCTION Hypothesis-driven studies have identified many modifiable cancer risk factors, but research focusing on single exposures overlooks their complex interactions. OBJECTIVES This study applied an exposome-wide approach across multiple cancer types to systematically identify modifiable exposures and evaluate...

Wen Liu, Shuai Xiang, Yi-Wei Liu et al. · 0 citations
Aug 2026

Cuproptosis enters the cancer-immunity circuit.

A reciprocal circuit in which cuproptotic tumor cells promote dendritic cell activation and CD8+ T cell priming, whereas T cell-derived IFN-γ sensitizes tumor cells to FDX1-dependent cuproptosis is revealed.

Yun Gao, N. Xing · 1 citation

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