Aug 2026· Cell· Vol 189 17, pp.
5154-5155
· 1 citation· 7 references
Medicine
TL;DR
A reciprocal circuit in which cuproptotic tumor cells promote dendritic cell activation and CD8+ T cell priming, whereas T cell-derived IFN-γ sensitizes tumor cells to FDX1-dependent cuproptosis is revealed.
Abstract
In this issue of Cell, Lei et al. reveal a reciprocal circuit in which cuproptotic tumor cells promote dendritic cell activation and CD8+ T cell priming, whereas T cell-derived IFN-γ sensitizes tumor cells to FDX1-dependent cuproptosis. This self-reinforcing interaction provides a mechanistic rationale for combining cuproptosis induction with PD-L1 blockade to overcome immunotherapy resistance.
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