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#gene editing Open access Oct 2026

Metabolic-epigenetic regulation of the HBV cccDNA reservoir: pathways underpinning viral persistence

Chronic hepatitis B virus (HBV) infection remains a global public health burden, and functional cure represents the primary goal of clinical management. The nuclear covalently closed circular DNA (cccDNA) minichromosome stably maintained in infected hepatocytes constitutes the major barrier to HBV cure. Clinically, f...

Qing Peng, Li-Yuan Hao, Sheng-Hao Li et al. · 0 citations
Open access Sep 2026

Genetic organization and mobile-element basis of β-lactam resistance in a polyclonal respiratory Haemophilus influenzae population

Haemophilus influenzae is an important respiratory colonizer and opportunistic pathogen. In the post-Hib vaccine era, non-type b and nontypeable strains have become increasingly associated with clinical disease, while β-lactam resistance complicates treatment and surveillance. To investigate the genet...

Xiao-Mei Xu, Yu-Peng Luo, Jun-Tao Tan et al. · 0 citations

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