Open access
Sep 2026
Site-resolved spatial and structural interactome of a human cell
The spatial and structural arrangement of proteins determine virtually every process in human cells. We combined gentle subcellular fractionation by differential ultracentrifugation with cross-linking mass spectrometry to systematically map this cellular proteome architecture with residue-level evidence, identifying 16...
Ze-Hong Zhang, Nanako Yokoyama, Ying Zhu et al.
· bioRxiv · 0 citations