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Natalie E. Connell

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#protein folding Open access Oct 2026

Photo-Activatable RNA Switches for Optical Control of Cell-Free Protein Synthesis

Programmable RNA switches enable target-dependent regulation of cell-free protein synthesis. Here, we report a photo-activatable RNA switch using photocleavable Lock DNA (pcl-Lock) to enable optical control of in vitro translation. Synthesized by solid-phase methods, pcl-Lock incorporates a coumarin-based photocleava...

Natalie E. Connell, Mahla Lashkari, Emmett Hanson et al. · 0 citations

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