Sequence‐encoded dynamics diversify allostery within a conserved protein scaffold
Abstract Proteins evolve allosteric mechanisms through sequence variation while preserving a conserved structural fold. How these substitutions reshape the protein's conformational landscape to drive functional diversification remains poorly understood. Members of the cAMP receptor protein family (CRP), a ubiquitous ba...
Sanuja Mohanaraj, Miray Samuel, Eva Siminiceanu et al.
· Protein Science · 0 citations