Author

Nico Zinn

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Open access Sep 2026

High-throughput platforms for genetic perturbation screening using CRISPR/Cas9 in human iPSC-derived macrophages for drug discovery

A scalable, semi-automated, and physiologically relevant hiPSC-derived macrophage model, rigorously characterised through deep comparative multi-omics is established and how genetic perturbations alter pro- and anti-inflammatory transcriptional signatures and significantly impact functional phenotypes are showcased.

Matteo Martufi, Eleni Karagianni, Tasos Papanikos et al. · bioRxiv · 0 citations

Open access Sep 2026

Cross-Platform Comparison of Chemoproteomics Workflows: Orbitrap-TMT Versus timsTOF-diaPASEF.

Chemoproteomics aims to achieve precise and comprehensive quantification of protein-small molecule interactions, yet methodological comparisons across quantitative proteomics workflows remain scarce. Here, we systematically benchmark tandem mass tag data-dependent acquisition (TMT-DDA) on Orbitrap Exploris/Eclipse inst...

Ursula M. Glocker, Michael Steidel, Henrik M. Hammarén et al. · Proteomics · 1 citation