De Novo Design of High-Affinity Minibinders Targeting the Occluded Head-Interface Epitope of Influenza A Hemagglutinin
Influenza A viruses pose a persistent global health threat due to rapid antigenic drift in the hemagglutinin (HA) globular head. The monomer-monomer head-interface epitope is highly conserved across epidemic H3N2 strains but sterically occluded within the intact HA trimer, rendering it inaccessible to full-size monoclo...