Full‐length brain‐derived α‐synuclein fibril models reveal fuzzy‐coat control of peptide recognition
A mechanistic model in which selectivity for aggregated aSyn arises from an emergent mesoscale interface combining a polyelectrolyte brush with recurrent core hotspots is presented, establishing full‐length, brain‐derived fibril ensembles as a practical framework for understanding ligand recognition at amyloid surfaces...
Carlos Pintado-Grima, Oriol Bárcenas, G. Tesei et al.
· Protein Science · 0 citations