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P. Avdonin

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Review Open access Aug 2026

Physiological Regulation and Pharmacology of Two-Pore Calcium Channels of the Endolysosomal System

This review characterizes the properties of two-pore channels and describes their regulation by phosphatidylinositol-3,5-bisphosphate and NAADP, changes in channel activity during cell starvation, as well as the effects on TPC channels exerted by sphingosine, protein kinases P38 and JNK, and regulatory proteins mTor, R...

P. Avdonin, S. K. Trufanov, N. V. Goncharov et al. · 0 citations

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