Aug 2026· Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology· Vol 20, pp. 256 - 274· 0 citations· 120 references
TL;DR
This review characterizes the properties of two-pore channels and describes their regulation by phosphatidylinositol-3,5-bisphosphate and NAADP, changes in channel activity during cell starvation, as well as the effects on TPC channels exerted by sphingosine, protein kinases P38 and JNK, and regulatory proteins mTor, Rab7a, and Tmem63a.
The calcium-activated chloride (ClCa) channel TMEM16A (also known as ANO1) is widely expressed in epithelial cells, interstitial cells of Cajal, nociceptive neurons and smooth muscle cells, where it plays essential roles in ion transport, neurotransmission and smooth muscle contraction. Dysfunction of TMEM16A channels...
H. Yamamura, Rubii Kondo, Yoshiaki Suzuki et al.· Journal of Physiology· 0 citations
Sodium-proton exchangers (NHEs) are found in all cells to regulate intracellular pH, sodium levels and cell volume. In humans, there are nine different NHE transporters (SLC9A1-9), which vary in tissue distribution, kinetics and regulation. NHE6 localizes to endosomal membranes and mutations in the protein are known to...
Suk-Han Jung, Hyunku Yeo, Hang Li et al.· Nature Communications· 0 citations
The Na+/K+-ATPase (NKA), commonly referred to as the sodium pump, is a ubiquitous membrane protein that maintains cellular homeostasis by expelling three sodium ions from the cell and importing two potassium ions using ATP hydrolysis. This enzyme is critical for maintaining resting membrane potential, generating ac...
Jia Tong, Liu-Yang Qin, Yun-Ge Zhang et al.· Frontiers in Cell and Develo...· 0 citations
How LRRK2-dependent trafficking mechanisms regulate key components of synaptic transmission, including glutamatergic and GABAergic receptors, as well as astrocytic transporters are examined, highlighting how disruption of these processes affects neurotransmitter clearance, receptor activation, and ultimately E/I balanc...
Angela Di Iacovo, C. D'Agostino, Giulia Casoli et al.· Cellular and molecular neuro...· 0 citations
This work identified the key molecular determinant in the hHv1 channel that mediates cholesterol inhibition and also provided a mechanism linking the conversion between demosterol and cholesterol by DHCR24 to pH homeostasis in many cells, such as phagocytes, cardiomyocytes, neurons and microglial cells.
Shuo Han, R. Duan, Sarah Applewhite et al.· bioRxiv· 0 citations
Podocytes and their foot processes form a functional layer of the glomerular filtration barrier. Due to their unique morphology and function, podocytes employ distinct nutrient pathways to maintain the bioenergetic balance, with lactate being one of several available energy substrates. Enhanced lactate intake modulates...
Klaudia Grochowalska, Maria Szrejder, Irena Audzeyenka et al.· International Journal of Mol...· 0 citations
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