Amyotrophic lateral sclerosis (ALS) is a heterogeneous neurodegenerative disorder lacking established biomarkers of underlying disease biology. Here, we identify lipidomic signatures of circulating extracellular vesicles (EVs) that distinguish ALS from neurologically healthy controls and related neuromuscular diseases....
V. Ricotti, A. Fogel, M. van den Bosch et al.· medRxiv· 0 citations
Traditional dementia research often isolates single aspects, biomarkers or symptoms, overlooking complex interactions shaping disease risk and progression. Lysosomal and mitochondrial dysfunction, reflecting systemic processes, may explain links between Alzheimer’s and metabolic, inflammatory, cardiovascular, ageing, g...
P. Barnaghi, Antigone Fogel, C. Walsh et al.· Communications Medicine· 0 citations
This work introduces a framework to evaluate the behavioral stability of LLM decision systems transforming IoT telemetry to semantic output, and argues behavioral stability in LLM-integrated IoT systems must be evaluated jointly with sensing reliability and regime structure.
J. A. D. López, Christopher Abou-Najm, Saksham Dawhan et al.· IEEE Internet of Things Jour...· 0 citations
This review explores the current state of AI in medicine, highlighting that current clinically mature and regulatory-approved products are based on deep learning architecture and are predominantly diagnostic.
Ahmad Guni, Wan-Heng Hu, Jess Morley et al.· Frontiers in Science· 1 citation
LLM4EHR, a new clinical foundation model trained on ICU EHR data, is proposed and it is found that learnt EHR TS embeddings from LLM4EHR improve performance on various downstream clinical tasks with competitive performance.
Jingteng Li, A. Capstick, Louise Rigny et al.· arXiv.org· 0 citations
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