Armoring STEAP1 CAR T cells with IL-18 potentiates antitumor activity in Ewing sarcoma
Ewing sarcoma (EwS) is an aggressive malignancy of children, adolescents, and young adults driven by the EWS::FLI1 fusion oncoprotein with few effective treatment options in the relapsed or refractory setting. We validate six transmembrane epithelial antigen of the prostate 1 (STEAP1) as a fusion-regulated and clinic...
Vipul Bhatia, Annabelle Tsao, Truman Chong et al.
· npj Precision Oncology · 0 citations