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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

P. Cullis

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Open access Sep 2026

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency.

Lipid nanoparticles (LNPs) are the leading platform for delivery of RNA-based therapeutics. There is considerable interest in optimizing the transfection potency of these systems. Standard formulation protocols involve mixing lipids in ethanol with a buffer containing mRNA at pH 4, followed by dialysis against a pH 7.4...

Yao Zhang, Jerry Leung, Judy Cheng et al. · 0 citations
Sep 2026

Programmable mRNA Nanotherapeutics through Logic Switch Design

A quantitative framework based on five key performance dimensions: dynamic range, temporal kinetics, output efficiency, spatial fidelity, and cycle retention is proposed, which discusses the emerging roles for computational modeling and artificial intelligence in enabling multiobjective optimization of these metrics an...

Pengwen Chen, Abdulaziz Alhussan, P. Cullis et al. · 0 citations

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