LncRNA-mediated organization of oncogenic chromatin state is a targetable vulnerability in leukemia

Zhenggen Jin Brendan D. Ma Karen Y. T. Chan Diana Lin D. Ghosh Amber Louwagie Luke Saville Joanne Liani Chandra Jennifer M. Grants Yi-Lin Liu Zongmin Liu Leo Escano Se-Wing Grace Cheng Sandra E. Spencer P. Stricker Glenn Edin Fiona Wong Kevin Dong Q. Hoang Quang Thang T. Bui Alexandria Schurer Kim Do T. Chou O. Christopher G. Basha Martin Sauvageau S. Hussein Gregg B. Morin Fabiana Perna Florian Kuchenbauer M. Kharas Aly Karsan P. Cullis L. Vu

Aug 2026 · bioRxiv · 0 citations

Biology

TL;DR

This study uncovers a therapeutic vulnerable lncRNA-centric circuitry and provides compelling preclinical evidence for the development and application of a novel RNA targeting-LNP based therapy for treatment of myeloid leukemia.

DOI Semantic Scholar

View source

Similar papers

Jul 2026

The lncRNA CTD-2566 J3.1 orchestrates oncogenic gene regulation via chromatin interactions in luminal breast cancer.

These findings establish CTD-2566 J3.1 as a multifunctional enhancer-associated lncRNA (e-lncRNA) that orchestrates key oncogenic processes in luminal breast cancer and underscores the utility of three-dimensional culture systems to reveal context-specific lncRNA functions.

Stephanie I. Nuñez-Olvera, L. R. Hernández-Barrientos, Elia Martínez-Baeza et al. · International Journal of Bio... · 0 citations

Review Open access 2026

The Mechanisms Underlying the Aberrant Expression and Oncogenic Role of SNHG1 in Cancer

A mechanism-driven approach is adopted to systematically examine SNHG1 dysregulation and its roles in cancer, which complements existing literature and provides a clear framework for future SNHG1 research.

Hao Zhou, Jian-Lin Zhou, Lin Zhou · Biocell (Mendoza) · 0 citations

Open access Jul 2026

Rbm5 sustains leukemia stem cells through a Myc-driven transcriptional circuitry.

It is reported that an unappreciated RNA-binding protein, Rbm5, selectively promotes murine leukemogenesis, maintains LSC self-renewal in vivo, and is dispensable for normal hematopoiesis.

Mengli Zhang, Shaela Fields, Qiong Zhang et al. · Leukemia · 0 citations

Open access Jan 2026

Integrative Pan‐Cancer Characterization of lncRNA UPK1A‐AS1 and Its Role in Hypoxia‐Associated Sorafenib Resistance in Hepatocellular Carcinoma

It is suggested that UPK1A-AS1 is a hypoxia‐inducible oncogenic lncRNA that plays dual roles in cancer, with cancer type‐dependent associations with progression and immune modulation across malignancies and mechanistically mediating hypoxia‐associated drug resistance in HCC.

Ze-Kai Li, Min Luo, Shu-Sen Fang et al. · Analytical Cellular Patholog... · 0 citations

Investigating the mechanism of lncRNA SChLAP1 in prostate cancer

A mechanism wherein SChLAP1 modulates AR signaling to promote PCa growth and progression is suggested, suggesting its molecular mechanism and potential to be used as a therapeutic target or biomarker.

Zoe Coutu, Srinivas Somarowthu · 0 citations

Review Open access Aug 2026

Dark matter matters: from noncoding RNA regulation to cancer immunity

These findings call for a revised molecular dogma in which the noncoding genome is recognized as a major regulator of cellular function, oncogenic transformation, and immune surveillance.

Maria Lteif, Assia Hijazi, E. Morgand et al. · Oncoimmunology · 0 citations