High‐throughput screening of the IMTM compound library for modulatory activity on adenosine receptors (ARs) identified two deazapurine hits based on 2,6‐diaryl‐7‐deazapurines. In this study, a series of 16 new 2,6‐diaryl‐7‐deazapurine nucleobases together with four N‐9 substituted derivatives were synthesized. The synt...
Ugnė Šinkevičiūtė, Kateřina Burgetová Ječmeňová, S. Gurská et al.· ChemMedChem· 0 citations
New N-(4-(chlorodifluoromethoxy)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives were designed, synthesised, and evaluated as potential anticancer agents. Among the synthesised derivatives, compound 9c showed the highest potency against BCR-ABL1-positive K562 leukemia cells, with an IC50 of 0.26 ± 0.029 µM,...
Pradeep B. Bhise, Sandeep B. Bhise, Somnath Dasgupta et al.· RSC Advances· 0 citations
Two series of 1,2,3‐triazole‐based molecules were synthesized. Their physical properties were documented, and cytotoxicity was evaluated against normal lymphocytes, leukemic, adherent, and nontumor cell lines. Compounds 11, 15, and 16 were inactive, while compound 17 affected both normal and cancer cells. Compounds 18...
A. Suárez, Katiuska Chávez, Pablo Martínez et al.· ChemMedChem· 0 citations
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