Targeting PI3K decreases trogocytosis-mediated CAR T cell fratricide
CAR T cell-mediated trogocytosis (CMT) is a proposed mechanism of tumor immune evasion, in which the cognate interaction between CAR T cells and tumor cells results in the transfer of target antigen from the tumor cell surface to the CAR T cell. In addition to the emergence of antigen-negative target cells, antigen-pos...
Tarang Sharma, Maday Galeana Figueroa, Kishan Kumar Nyati et al.
· Leukemia · 0 citations