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Author

Pauline Hermans

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Review Jul 2026

Engineering T7 RNA Polymerase for High-Purity In Vitro Transcription

In vitro transcription using bacteriophage T7 RNA polymerase (T7 RNAP) is the gold-standard platform for RNA production in both research and therapeutic applications. Despite its high processivity and promoter specificity, T7 RNAP generates multiple RNA by-products, including double-stranded RNA, 3'-extended transcript...

Pauline Hermans, Y.I. Serikova, J. Castillo et al. · 0 citations
Open access Aug 2026

Assessing Computational Models for Pharmacogenomic Variant Interpretation

Assessment of several computational approaches using a dataset of pharmacogenomic variants with either clinical annotations or functional characterization by deep mutational scanning, with an additional focus on CYP2C9, a clinically relevant drug-metabolizing enzyme, indicates that computational models can complement i...

F. Pucci, Pauline Hermans, Matsvei Tsishyn et al. · 0 citations

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