Open access
Aug 2026
Synthesis and Biological Activity of 2,6‐Disubstituted and 2,6,9‐Trisubstituted 7‐Deazapurine Nucleobases
High‐throughput screening of the IMTM compound library for modulatory activity on adenosine receptors (ARs) identified two deazapurine hits based on 2,6‐diaryl‐7‐deazapurines. In this study, a series of 16 new 2,6‐diaryl‐7‐deazapurine nucleobases together with four N‐9 substituted derivatives were synthesized. The synt...
Ugnė Šinkevičiūtė, Kateřina Burgetová Ječmeňová, S. Gurská et al.
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