Author

Pengcheng Ma

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#protein folding Open access Sep 2026

CCNB1IP1 regulatory evolution underlies gradual increases in cortical size and folding in primates.

The gradual expansion and folding of the cortex are key factors in human cognitive evolution, yet their molecular underpinnings remain not well understood. Here we identify cyclin B1 interacting protein 1 (CCNB1IP1) gene as a key regulator of human brain evolution using tree shrew as an outgroup. In primates, CCNB1IP1...

Ting Hu, Peng-Cheng Ma, Yi-Fan Kong et al. · Nature Genetics · 0 citations

Open access Jul 2026

RNF220 safeguards meiotic synapsis and male fertility by antagonizing SYCE1 ubiquitination

A homozygous mutation in RNF220 , encoding a RING-type E3 ubiquitin ligase, is associated with male infertility featuring small-headed sperm, but the precise roles and mechanisms of RNF220 in spermatogenesis remain elusive. Here, we explored the function of RNF220 in spermatogenesis using a Stra8-Cre-mediated...

Jing-Mei Cha, Huijuan Lin, Yingqian Xia et al. · Cell Death & Disease · 0 citations

Open access Jul 2026

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

ABSTRACT In the central nervous system, oligodendrocytes (OLs) generate myelin sheaths to support rapid nerve impulse conduction. OL lineage cells, especially oligodendrocyte precursor cells (OPCs), feature high metabolic activity and are exposed to severe oxidative stress, but the protective mechanisms remain poorly u...

Yuwei Li, Haijun Zhang, Jieya Zhou et al. · Advancement of science · 0 citations