Pengfei Yang

Endovascular treatment after stroke beyond 24 h vs 6-24 h: a propensity score-matched cohort study.

BACKGROUND Endovascular thrombectomy (EVT) is the standard treatment for acute ischemic stroke due to anterior circulation large vessel occlusion (LVO) within 6-24 h. However, the safety and feasibility of EVT for anterior circulation strokes beyond 24 h remain uncertain. METHODS We conducted a retrospective cohort s...

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

ABSTRACT Mitochondria, as organelles with a critical role in maintaining cellular activities, are also vulnerable to dysfunction, which contributes substantially to the pathogenesis of various systemic diseases. Nanomaterials, owing to their tunable physicochemical properties and precise bio‐interfacial capabilities, o...

Ketone Bodies in Ischemic Stroke: A Review of Neuroprotective Mechanisms and Therapeutic Implications.

Ischemic stroke disrupts cerebral metabolism and initiates a cascade of pathological events, including excitotoxicity, mitochondrial dysfunction, and neuroinflammation. These interconnected processes drive neuronal apoptosis, necrosis, and synaptic loss, ultimately leading to irreversible brain injury, persistent neuro...

Feasibility of a novel multi-device robotic system for multiple neurointerventional procedures: pre-clinical validation in porcine models