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CRISPR spacer-based host-virus linkage analysis is applied to 3,229 myxobacterial genomes and identified 790 nonredundant myxophages spanning diverse global ecosystems, substantially expanding the myxoviral diversity and providing insights into virus-host interactions and evolutionary adaptation of myxophages.
The Qinghai-Tibet Plateau, a climate-vulnerable source of Asia’s major rivers, harbors underexplored viral communities critical to ecosystem functions. By integrating 597 metagenomes from the Yangtze, Yellow, Lancang, and Yarlung Tsangpo rivers with 85 public available glacial metagenomes (Tibetan Glacier Genome and Ge...
A systematic ESKAPE virome resource is established, phages’ dual roles in targeting resistant pathogens and curbing resistance spread are demonstrated, and mechanistic support for phage therapy clinical application is provided.
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