TL;DR
A systematic ESKAPE virome resource is established, phages’ dual roles in targeting resistant pathogens and curbing resistance spread are demonstrated, and mechanistic support for phage therapy clinical application is provided.
Findings highlight the contribution of plasmids to the dissemination of phage-resistance traits, underscore the importance of the mobilome in shaping phage-resistance landscapes in multidrug-resistant pathogens, and support the incorporation of plasmid defense profiling into phage therapy design.
It is demonstrated that R-pyocins can be leveraged not merely as conventional biocides, but as precise selective forces to drive an evolutionary “checkmate” strategy, establishing a framework for using R-pyocins to force predictable evolutionary trade-offs, driving the reversion of multidrug resistance to an attenuated...
ABSTRACT Vibrio sinaloensis has been reported in association with disease events in aquaculture, yet its genomic features and non-antibiotic suppression strategies remain largely unexplored. Here, we report genomic characterization of a multidrug-resistant V. sinaloensis strain, ZZ006, isolated from diseased shrimp and...
Critical insights into the development of multidrug resistance in nosocomial pathogens are provided and could enlighten novel drug designs and strategies to combat infections in both clinical and environmental settings.
Comparative analyses across wastewater, sludge, and food matrices demonstrate that crAssphage mirrors ARG trends, remaining detectable even when conventional bacteria decline, and support integrating crAss-like phages as functional indicators in environmental surveillance frameworks.
The increasing clinical evidence shows that synthetic biology can effectively overcome the inherent defects of natural bacteriophages, confirming the safety and initial efficacy of bacteriophage therapy.
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