Author

Pierre Genevaux

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Review Aug 2026

Tripartite toxin-antitoxin systems: expanding the paradigm of molecular interplay and antiphage defense.

Prokaryotic toxin-antitoxin (TA) systems are genetic modules involved in stress responses, including antiphage defense and the maintenance of mobile genetic elements. Although canonical TA systems consist of two neighboring genes encoding one toxin and one antitoxin, many have evolved into tripartite systems through th...

Yun-Xue Guo, Pierre Genevaux, Xiaoxue Wang · Trends in Microbiology · 0 citations

#protein folding Open access Sep 2026

Adaptability of the GroEL/GroES chaperonin to proteostatic challenge revealed by directed evolution.

The folding of newly synthesized proteins is assisted by an essential network of proteins known as molecular chaperones. In bacteria, the chaperones Trigger Factor (TF), DnaK/DnaJ (Hsp70 system), and GroEL/GroES (chaperonin system) are key players in proteostasis maintenance. Here, we further explore the cooperation an...

Marie-Pierre Castanié-Cornet, Tatsuya Niwa, É. Dupuy et al. · Proceedings of the National... · 0 citations