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Author

Pierre-Luc Boudreault

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Open access Aug 2026

TMPRSS6 Cleavage of β-Klotho Modulates FGF19 Signaling

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disorder worldwide, yet therapeutic options remain limited. TMPRSS6, a liver serine protease best known for its role in iron homeostasis, has recently emerged as a potential therapeutic target for MASLD. However, the molecular...

Matthieu Lepage, A. Désilets, Gabriel Lemieux et al. · 0 citations
Jul 2026

Peptide ligand discovery of G protein-coupled receptors

This Primer outlines experimental and computational workflows tailored to peptide–GPCR interactions, including in silico peptide mining, deorphanization strategies, library-based screening platforms, modern pathway-resolved biosensor assays, and approaches for peptide stabilization and optimization strategies to addres...

J. Hermes, Marin Matic, H. Yeung et al. · 0 citations

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