Beyond gene editing: the age of chromosome-scale genome engineering.
How advances in large DNA assembly, synthetic biology, and genome-wide validation are making chromosome-scale genome engineering an increasingly tractable experimental framework for understanding, building, and repairing genomes is discussed, while outlining the analytical requirements and current technical barriers th...
Miriam Saponaro, Pierre Murat, Francesca Agostini et al.
· Trends in Genetics · 0 citations