Author

Ping Wang

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#protein folding Open access Sep 2026

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

ABSTRACT Spinal cord injury (SCI) is a devastating disorder of the central nervous system (CNS) leading to irreversible neurological deficits. Effective pharmacotherapy remains elusive, due to the restrictive blood‐spinal cord barrier (BSCB), underscoring the urgent need for targeted and efficient drug delivery strateg...

Yi-Xuan Wang, Bo Jin, Shi-Pian Li et al. · Advancement of science · 0 citations

Open access Jul 2026

Targeted degradation of hepatic KEAP1 mitigates drug-induced liver injury via dual boosting NRF2 and PGAM5 signaling

Oxidative stress and impaired mitochondrial homeostasis are critical drivers of drug-induced liver injury (DILI), both of which are negatively regulated by Kelch-like ECH-associated protein 1 (KEAP1). In this study, a dual-action strategy was adapted to develop a novel KEAP1 degrader with high liver exposure for mitiga...

Yanyan Deng, Leizhi Xu, Xiaoting Niu et al. · Redox Biology · 0 citations