Targeting Covalently Closed Circular DNA (cccDNA): Emerging Therapeutic Strategies Toward a Functional Cure for Chronic Hepatitis B
Chronic HBV won't be resolved in the immediate future. Almost 300 million individuals live with it [1], as well as it causes roughly 820,000 deaths annually [1]—mainly due to conditions such as cirrhosis, liver failure, or liver cancer. The usual therapies, such as nucleos(t)ide analogues and pegylated interferon-alpha...