UPLC-ESI-MS based lipidomics revealed novel biomarkers in insulin receptor knockdown induced type 2 diabetes model of Drosophila
T2D like model was established by inducing insulin resistance through knockdown of the insulin receptor in brain insulin-producing cells using the dilp2-Gal4>UAS-InRRNAisystem, which resulted in significant metabolic dysregulation, including elevated glucose, trehalose, and triacylglyceride levels, along with increased...