T2D like model was established by inducing insulin resistance through knockdown of the insulin receptor in brain insulin-producing cells using the dilp2-Gal4>UAS-InRRNAisystem, which resulted in significant metabolic dysregulation, including elevated glucose, trehalose, and triacylglyceride levels, along with increased oxidative stress indicators.
Type 2 diabetes (T2D) became the most prevalent metabolic diseases worldwide characterized by insulin resistance (IR). Nomilin is a bioactive triterpene compound primarily found in citrus fruits and its anti-diabetes effect has been preliminary studied. This study combined network pharmacology, bioinformatics analy...
Jin-Can Luo, Jin-Hai Luo, Bin-Cheng Han et al.· Food Science and Human Welln...· 0 citations
Diabetes mellitus (diabetes) is a major health burden with the highest mortality rate, affecting an estimated 537 million adults worldwide. The treatment of diabetes remains complex owing to insulin resistance, β-cell dysfunction, metabolic inflammation, and progressive organ damage. While G-protein-coupled receptors (...
Sureka Chandrabose, Vikraman Muniyandi, Ayman Geddawy et al.· Frontiers in Endocrinology· 0 citations
FHT mitigates podocyte injury by reshaping lipid metabolic homeostasis via multiple targets, providing a strong mechanistic basis for its clinical use in NS.
Z. Xue, Meng-Jiao Wang, Ting Linghu et al.· Journal of chromatography. B...· 0 citations
Diabetes mellitus and cancer are among the most prevalent chronic diseases worldwide, and accumulating evidence suggests a significant association between these conditions. The metabolic disturbances characteristic of diabetes, including hyperglycemia, hyperinsulinemia, insulin resistance, and chronic inflammation, cre...
Nahed S. Alharthi· American Journal of Cancer R...· 0 citations
Obesity and type 2 diabetes (T2D) represent a major globalhealth burden, with increasing prevalence linked to sedentary lifestyles, poor dietary habits, and genetic predisposition. These conditions are strongly interconnected through a range of metabolic dysfunctions, including insulin resistance, chronic inflammation,...
Nakawungu Catherine· IDOSR JOURNAL OF EXPERIMENTA...· 0 citations
Statins are a commonly prescribed cholesterol-lowering drug class that can increase the risk of new-onset diabetes (NOD). The underlying molecular mechanisms have yet to be fully elucidated. We aimed to identify molecular factors associated with differential susceptibility to NOD and determine their effects on β-...
Yu-Lin Kuang, C. Locatelli, Yu-Qing Zhang et al.· Cardiovascular Diabetology· 0 citations
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