Pranav Machingal

Position-wise Fold-Switch Prediction in Metamorphic Proteins: A Comparison of Handcrafted and Language Model Features

In this work, we focus on predicting fold-switching phenomena observed in certain protein structures. Proteins that undergo fold-switching are called metamorphic proteins. We model fold-switch prediction in proteins as a position/residue-wise classification task. We use various features extracted from a protein’s seque...