Spatiotemporal Nanotherapy After Myocardial Infarction: Targeting the Inflammatory-to-reparative Transition With Extracellular Vesicles and Engineered Nanoparticles.
This review evaluates how extracellular vesicles, cell-derived nanovesicles, and engineered nanoparticles can be matched to these changing biological requirements to demonstrate phase-dependent target availability, controlled exposure, target-cell cargo engagement, and reduced benefit or emerging harm with a deliberate...