Spatiotemporal Nanotherapy After Myocardial Infarction: Targeting the Inflammatory-to-reparative Transition With Extracellular Vesicles and Engineered Nanoparticles.
Sep 2026· Cardiovascular Drugs and Therapy· 0 citations· 91 references
Medicine
TL;DR
This review evaluates how extracellular vesicles, cell-derived nanovesicles, and engineered nanoparticles can be matched to these changing biological requirements to demonstrate phase-dependent target availability, controlled exposure, target-cell cargo engagement, and reduced benefit or emerging harm with a deliberately mismatched schedule.
Cardiovascular disease remains a major cause of morbidity and mortality worldwide, with myocardial infarction and pressure overload driving progressive cardiac injury and maladaptive remodeling that involve dynamic changes in vasculature, cells, and extracellular matrix. Current therapies do not fully prevent this proc...
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Ischemic stroke reperfusion injury is driven by oxidative stress and neuroinflammation, but current neuroprotective strategies suffer from poor targeting, limited functionality, and low blood‑-brain barrier (BBB) penetration. Herein, a multifunctional nanoplatform (RM@HPAN) is constructed: a hollow mesoporous Prussian...
Myocardial infarction (MI) involves a temporally evolving pathological cascade, in which acute NLRP3 inflammasome-mediated inflammation and insufficient reparative angiogenesis sequentially contribute to adverse ventricular remodeling. However, most current therapies lack the spatiotemporal control needed to match thes...
Yuan-Bin Luo, Ren-Sheng Song, Yang Yang et al.· Materials Today Bio· 0 citations
Myocardial infarction (MI) progresses through a series of distinct pathological stages, from acute ischemia and reperfusion injury to chronic inflammation, fibrotic proliferation, and ventricular remodeling, each characterized by a unique combination of microenvironmental cues and therapeutic demands. Traditional injec...
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