Protein homeostasis, or proteostasis, is essential for cellular health, and its disruption contributes to cancer, aging, and neurodegenerative disease. Proteostasis is maintained largely by two intracellular degradation systems: the ubiquitin proteasome system (UPS) and the autophagy lysosomal pathway (ALP). Here, we c...
Zi Gao, Qiang Xiao, Jeffery W. Kelly et al.· bioRxiv· 0 citations
The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis network, a highly interconnected system of over 3000 components that regulate protein synthesis, folding, localization, and degradation....
Evan T. Powers, Suzanne Elsasser, Ee Phie Tan et al.· Autophagy· 1 citation
Lung cancer is the leading cause of cancer-related death worldwide, and non-small cell lung cancer accounts for approximately 85% of all cases. Although immune checkpoint inhibitors have transformed the therapeutic landscape, downregulation of the major histocompatibility complex and chronic immunosuppression in...
Yi-Ge Wang, Qiang Xiao· Journal of Translational Med...· 0 citations
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