Ultrasound-responsive nanotheranostic systems for glioblastoma: Materials evolution, design strategies and clinical translation perspectives
Glioblastoma (GBM) remains one of the most aggressive primary brain malignancies, characterized by a poor prognosis and limited therapeutic efficacy due to the restrictive nature of the blood–brain barrier (BBB), marked tumour heterogeneity, and the rapid development of therapeutic resistance. These challenges signific...