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Author

R. Flavell

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Aug 2026

TIF1γ regulates stability of regulatory T cells during inflammation

It is shown that TIF1γ-deficient Treg cells lose Foxp3 expression and acquire effector phenotypes in a cell-intrinsic manner upon inflammatory challenge, and TIF1γ is identified as a critical regulator of Treg cell stability that restrains β-catenin–TCF7 signaling.

Eugenio Contreras-Castillo, Jesús Daniel Zambrano-Romero, H. N. Núñez-Martínez et al. · 1 citation
Open access Jul 2026

Targeting DNMT1 augments anti-tumor CD8⁺ T cell function

DNMT1 targeting is established as a promising strategy to counteract CD8⁺ T cell exhaustion and potentiate ICI efficacy and enhances the effector function of melanoma patient-derived tumor infiltrating lymphocytes after prolonged ex vivo expansion.

M. Deshmukh, Danielle K. Sohai, Kamal Obbad et al. · 0 citations

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