Author

R. Harris

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Open access Sep 2026

APOBEC3 Knockout in Lentiviral Packaging Cells Improves Therapeutic Transgene Sequence Fidelity.

Lentiviral vectors are a well-established method of delivering transgenes into target cells. Lentiviral vectors have a strong efficacy and safety profile, but transgene fidelity remains an area of concern. Loss of function mutations within the integrated transgene may reduce therapeutic efficacy. Gain of function mutat...

Annika Mittelhauser, R. Patel, Alex B. Costa et al. · Molecular Therapy · 0 citations

Open access Aug 2026

APOBEC3G Splicing Defects in Nonhuman Primate Models Result in Disparate Viral Mutational Profiles Relative to Humans

It is reported that APOBEC3G (A3G), a potent antiviral restriction factor and the major source of genetic variations in HIV, exhibits a widespread mRNA splicing defect in the Cercopithecinae subfamily, which includes the commonly used NHP models.

A. Mendez, Rachael Springman-Rodriguez, Ayub Bokani et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

Scarless SARS-CoV-2 Genome Engineering and Variant Analysis

A genome engineering technology is used to change a single amino acid in the viruses’ main protease enzyme to match that of circulating Omicron isolates to demonstrate antiviral efficacy of approved drugs and uncover mutants with reduced drug sensitivity.

Agnieszka Dabrowska, Ashley Cuell, Rahul Basu et al. · bioRxiv · 0 citations