Cells resist viral infection by triggering rapid and sensitive innate immune responses, initiated by cytoplasmic viral sensor proteins (CyVSP), retinoic acid-inducible gene I (RIG-I), melanoma differentiation-associated protein 5 (MDA-5), and protein kinase R (PKR). Our single-cell analysis reveals that viral replicati...
Kojiro Mukai, D. Jia, Mamata Panigrahi et al.· Cell· 0 citations
In humans, long-term hematopoietic stem cells (LT-HSCs) are enriched within the CD34⁺CD38
low
fraction in vivo, and CD38 abundance typically rises with lineage commitment, suggesting that CD38 may function as a negative regulator of stem cell function. Here, we show that pharmacologic CD38 inhibition with 78c dur...
Jian-Yi Ding, Daisuke Araki, Yong-Qin Li et al.· Cell Death & Disease· 0 citations
PAK1 and PAK2 shielded RAS from LZTR1-dependent degradation by phosphorylating T148, and inhibiting PAK1/2 activity improved RAS-directed therapy, revealing a regulatory circuit governing RAS stability that is preferentially active in blood cancers and potentially druggable.
Lin Zhang, A. Bolomsky, Omar S. Al-Odat et al.· Blood Cancer Discovery· 0 citations
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