The authors' findings reveal separable effects on TLR trafficking, downstream signalling and inflammasome activation, identifying CNPY3 as a key regulator of multiple cellular pathways involved in inflammatory responses and neurodevelopment.
Vera Garloff, M. Grimmel, R. Maroofian et al.· EBioMedicine· 0 citations
PURPOSE
GAD67 and GAD65, encoded by GAD1 and GAD2, respectively, are the two isoforms of glutamic acid decarboxylase (GAD), the enzyme responsible for γ-aminobutyric acid (GABA) synthesis. Pathogenic variants in GAD1 cause a severe developmental and epileptic encephalopathy, whereas GAD2 has not previously been implica...
Mathijs B. van der Lei, Matthias De Wachter, C. D'Incal et al.· Genetics in Medicine· 0 citations
Aminoacyl-tRNA synthetase complex interacting multifunctional protein 2 (AIMP2) is a component of the eukaryote-specific multisynthetase complex (MSC), a macromolecular assembly of eight aminoacyl-tRNA synthetases (ARS) and three scaffolding components known as aminoacyl-tRNA synthetase interacting multifunctional prot...
P. Mullen, Shenela Lakhani, Joshua Appelbaum et al.· The FEBS Journal· 0 citations
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