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Author

R. McIntyre

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Review Sep 2026

Pharmacological interventions for acute major depression and bipolar depression with mixed features: A systematic review and dose-related network meta-analysis across different age groups.

BACKGROUND Acute mixed bipolar/major depression is relatively frequent, yet quantitative information about its pharmacological management is relatively scant, warranting network meta-analysis (NMA) of comparative efficacy/response/acceptability of pharmacological interventions accounting for dose effects across differe...

M. Fornaro, C. Di Lorenzo, Nicolas A. Nunez et al. · 0 citations
Open access Sep 2026

193. Efficacy and safety of adjunctive lumateperone 42 mg in major depressive disorder: pooled analysis of demographic and clinical subgroups from Phase 3 randomized placebo-controlled trials

Abstract Background Major depressive disorder (MDD) presents with highly variable clinical symptoms and treatment responses. Patient characteristics can impact treatment outcomes, making it essential to evaluate efficacy across subgroups to establish consistency of treatment effects. Lumateperone is an FDA-approved ant...

W. Earley, S. Durgam, C. Chen et al. · 0 citations
Open access Jul 2026

Elunetirom, a brain-targeted TRβ prodrug, promotes neuronal plasticity and mitochondrial biogenesis-related signaling in primary neuronal cultures

It is indicated that elunetirom and LL- 340001 engage complementary neuroplasticity and mitochondrial biogenesis-related programs in neuronal systems and support further investigation of brain-targeted thyromimetic signaling as a mechanistically differentiated approach for major depressive disorder and bipolar depressi...

Jason R. Harris, Jill Baccei, W. Stratton et al. · 0 citations

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