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Elunetirom, a brain-targeted TRβ prodrug, promotes neuronal plasticity and mitochondrial biogenesis-related signaling in primary neuronal cultures

Jason R. Harris Jill Baccei W. Stratton S. Stahl R. McIntyre Thomas S Scanlan G. Davar
Jul 2026 · bioRxiv · 0 citations · 35 references
Biology

TL;DR

It is indicated that elunetirom and LL- 340001 engage complementary neuroplasticity and mitochondrial biogenesis-related programs in neuronal systems and support further investigation of brain-targeted thyromimetic signaling as a mechanistically differentiated approach for major depressive disorder and bipolar depression.

DOI Semantic Scholar
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