Loss-of-function mutations in PRKN cause early-onset Parkinson’s disease, and the prevailing model attributes the resulting neurodegeneration to failed mitochondrial quality control. We find that Parkin loss also rewires the genetic dependencies that govern neuronal survival. Isogenic Prkn-/-rat cortical neurons died a...
Shi-Jie Wang, D. Gulbranson, Beatrice Costa et al.· bioRxiv· 0 citations
A tissue-based transcriptional environment in which SARS-CoV-2 activates innate myeloid immune signaling, driving chronic inflammation while simultaneously downregulating pathways responsible for immune-mediated clearance of infected cells is identified, including antigen presentation, phagocytosis, cytotoxic immune ce...
B. LaFranchi, David P. Maison, J. Vinden et al.· bioRxiv· 0 citations
Tau reduction supports the potential benefits and safety of overall tau reduction and the hypothesis that even physiological forms of tau can allow pathogenic triggers such as AD-mutant APP and PS1 to elicit aberrant neuronal activities and synaptic degeneration.
Sara J. Knowles, Cathrine Sant, Pranav Nambiar et al.· bioRxiv· 0 citations
