Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID

B. LaFranchi David P. Maison J. Vinden Antonio E. Rodriguez Ali Tout Lilian Grimbert Emanuel Velazquez Urmila Vudali Belen E. Altamirano Poblano T. Dalhuisen Javier D. Cattle Tony Figueroa Yuki Fudotan Michael Luna Dylan Ryder M. Deswal B. Abel James Lynch Amanda Lipford N. Razi C. Steifman H. McCann Nick Kataria V. Girling R. Thomas Chao Wang A. Deitchman Shreya Patel Michela Traglia Zian H. Tseng Gyula Szabó Zoltan G. Laszik Alex Farrow N. Zwart N. Sumimoto V. Servellita R. Hoh Emily A. Fehrman J. D. Kelly Jeffrey N. Martin S. Deeks Charles Y. Chiu Ma Somsouk M. Peluso Timothy J. Henrich

Aug 2026 · bioRxiv · 0 citations

Biology

TL;DR

A tissue-based transcriptional environment in which SARS-CoV-2 activates innate myeloid immune signaling, driving chronic inflammation while simultaneously downregulating pathways responsible for immune-mediated clearance of infected cells is identified, including antigen presentation, phagocytosis, cytotoxic immune cell trafficking, and granzyme production.

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