Rajendra Prasad Roy

Crystal structure of pilus-specific sortase from Enterococcus faecalis reveals both open and closed conformations: insights into loop dynamics and substrate recognition.

The unprecedented structural snapshots of both open and closed lid conformations, synchronized with the proline switch in the β7-β8 loop, captured in the same crystal structure, advance the understanding of sortase-mediated virulence in enterococci and provide a framework for the development of antivirulence strategies...