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Crystal structure of pilus-specific sortase from Enterococcus faecalis reveals both open and closed conformations: insights into loop dynamics and substrate recognition.

Vinay Sharma Sumit Murmu Rajendra Prasad Roy V. Krishnan
Aug 2026 · Acta Crystallographica Section D: Structural Biology · Vol 82, pp. 947-961 · 0 citations
Medicine

TL;DR

The unprecedented structural snapshots of both open and closed lid conformations, synchronized with the proline switch in the β7-β8 loop, captured in the same crystal structure, advance the understanding of sortase-mediated virulence in enterococci and provide a framework for the development of antivirulence strategies.

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