Integrated Proteome and Phosphoproteome Profiling Reveals Abundance-Independent Phosphorylation Remodeling in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is characterized by extensive molecular heterogeneity, yet changes in protein abundance alone may not fully capture the regulatory alterations that drive tumor biology. Here, we performed integrated whole-proteome and phosphoproteome profiling of paired HCC and adjacent non-tumorous liver...