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Author

Rhea P. Desai

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Open access Jul 2026

Structure-based recasting of a mammalian DNA transpososome as an obligate heterodimer

It is found that identical amino-acid sequence motifs adopt distinct roles to mediate two modes of DNA binding: one to perform strand transfer and one, devoid of catalytic activity, that promotes synapsis while simultaneously protecting the transposon from auto-destructive internal cleavage by its active sites.

Raju Mandal, A. Hickman, Rhea P. Desai et al. · 0 citations
#protein folding Open access Aug 2026

A thermodynamic framework for mapping elastic recoil mechanism across the human proteome

A sequence-derived thermodynamic framework is introduced that maps proteins according to the relative contributions of backbone conformational entropy and solvent entropy to elastic recoil, suggesting that elastic function is far more widespread than currently recognized.

Rhea P. Desai, D. Pople, Shreyas Jain et al. · 0 citations

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